Prevention of Aspiration Pneumonia at Induction of General Anesthesia; By Single Dose Omeprazole versus Esomeprazole.

Abstract

Objectives: The objective of this study was to evaluate and compare the effectiveness of single dose of omeprazole 40mg versus esomeprazole 40mg on gastric acidity (stomach PH). Methodology: This was a prospective comparative study on 50 patients, undergoing elective inguinal hernia surgery were included. Two groups were given omeprazole and esomeprazole 40 mgs respectively a night before surgery to see effect on gastric PH. Results: In group “O” the median range of gastric fluid pH was 4.5 (1.5-7.0). In group “E” it was 7.0 (3.0-8.0). P value is not significant. Conclusion: Single oral dose of Esomeprazole 40mg at bed time before surgery has same efficacy and results to increase the intra-gastric pH like single oral dose of Omeprazole 40mg.